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Chen et al. proposed the use of novel nano-formulation procedures to focus on shipping and delivery of such phytonutrients. The cumulative transport and bioavailability of nano-EGCG was about 2 times of cost-free EGCG, plus the dose advantage of nano-EGCG to induce apoptosis in prostate cancer cells was much more than 10 situations (178).Nasal infl